Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Auditory efferent function is affected in multiple sclerosis.

Albert Coelho1, Borka Ceranić, Deepak Prasher

  • 1Department of Neuro-Otology, The National Hospital for Neurology and Neurosurgery, United Kingdom.

Ear and Hearing
|September 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Projection of Interspecific Competition (PIC) Matrices: A Conceptual Framework for Inclusion in Population Risk Assessments.

Environmental toxicology and chemistry·2024
Same author

AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male-Biased Sex Ratio and Population Decline in Fish.

Environmental toxicology and chemistry·2023
Same author

Investigating Vernal Pool Fairy Shrimp Exposure to Organophosphate Pesticides: Implications for Population-Level Risk Assessment.

Ecologies·2022
Same author

A Multidimensional Matrix Model for Predicting the Effects of Male-Biased Sex Ratios on Fish Populations.

Environmental toxicology and chemistry·2022
Same author

Diagnostic accuracy and usability of the EMBalance decision support system for vestibular disorders in primary care: proof of concept randomised controlled study results.

Journal of neurology·2021
Same author

A 30-Year Study of Impacts, Recovery, and Development of Critical Effect Sizes for Endocrine Disruption in White Sucker (<i>Catostomus commersonii</i>) Exposed to Bleached-Kraft Pulp Mill Effluent at Jackfish Bay, Ontario, Canada.

Frontiers in endocrinology·2021
Same journal

Community-Informed Adaptation of a School-Based Hearing Health Intervention: Formative Evaluation for an Effectiveness-Implementation Trial.

Ear and hearing·2026
Same journal

Hearing Difficulty, Health Literacy, and Poorer Health Among Adults in the United States: 2016 Behavioral Risk Factor Surveillance Study.

Ear and hearing·2026
Same journal

Cultural Differences in Listening Environments Between Hispanic and White Non-Hispanic Cochlear Implant Users.

Ear and hearing·2026
Same journal

Detection of Inner Ear Malformations Based on Simple Anatomical Measurements: A Model Approach.

Ear and hearing·2026
Same journal

Avoiding Cisplatin-Related Hearing Loss, Including Implementing Sodium Thiosulfate as Otoprotectant Into Daily Pediatric Clinical Practice: Proceedings Based on Evidence and Expert Opinion From the Ototoxicity Taskforce of the SIOP Supportive Care Network.

Ear and hearing·2026
Same journal

Quantifying Miscommunications in Triadic Conversations: Effects of Hearing Impairment, Hearing Aids, and Background Noise.

Ear and hearing·2026
See all related articles

Multiple sclerosis (MS) patients often show reduced efferent auditory function, impacting the medial olivocochlear (MOC) pathway. The MOC suppression test may help detect subtle brain stem lesions in early MS diagnosis.

Area of Science:

  • Neuroscience
  • Otolaryngology
  • Auditory Neuroscience

Background:

  • Multiple sclerosis (MS) is characterized by various auditory abnormalities, yet efferent auditory pathway function remains understudied.
  • The medial olivocochlear (MOC) pathway, crucial for auditory processing, may be affected by MS due to predilection for brain stem lesions.

Purpose of the Study:

  • To evaluate efferent medial olivocochlear (MOC) function in patients with multiple sclerosis (MS).
  • To investigate the correlation between MOC function deficits and the presence/location of MS-related brain lesions.
  • To explore the diagnostic potential of the MOC suppression test in MS.

Main Methods:

  • Assessed MOC function using the olivocochlear suppression test with transient evoked otoacoustic emissions.

Related Experiment Videos

  • Included 30 MS patients (10 with brain stem lesions, 20 without) and 22 healthy controls.
  • Utilized standard auditory tests including pure-tone audiometry and auditory brain stem evoked responses.

    • Main Results:

    • Reduced MOC function was observed in 66.6% of MS patients.
    • 90% of patients with brain stem lesions exhibited abnormal MOC function.
    • Abnormal MOC function was also found in 55% of patients without evident brain stem lesions on MRI.

    Conclusions:

    • A significant deficit in efferent auditory function exists in the majority of MS patients.
    • Abnormal MOC suppression may explain overlooked auditory symptoms in MS.
    • The MOC suppression test shows promise as a sensitive diagnostic tool for detecting subtle brain stem lesions and aiding early MS diagnosis.