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Updated: Aug 1, 2026
14:28
Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
[Inadequate ADH secretion syndrome associated with acquired immunodeficiency syndrome]
I Santos Gil1, I García Polo, C del Arco Galán
1Servicio de Medicina Interna-Infecciosas, Hospital de la Princesa, Madrid.
Revista Clinica Espanola
|February 1, 1991
Summary
Inadequate ADH secretion syndrome (IADHSS) is more common in AIDS patients, often linked to lung or CNS issues. Suspect IADHSS or adrenal problems if AIDS patients present with hyponatremia.
Area of Science:
- Endocrinology
- Infectious Diseases
- Neurology
Context:
- Acquired Immunodeficiency Syndrome (AIDS) is associated with various complications.
- Hyponatremia is a frequently observed electrolyte imbalance in patients with AIDS.
- The specific causes of hyponatremia in AIDS patients require further investigation.
Purpose:
- To investigate the occurrence and potential causes of inadequate ADH secretion syndrome (IADHSS) in patients with AIDS.
- To determine the association between IADHSS and specific pathologies in AIDS patients.
- To highlight the importance of considering IADHSS in the differential diagnosis of hyponatremia in AIDS.
Summary:
- Inadequate ADH secretion syndrome (IADHSS) was identified in 9 AIDS patients, a higher prevalence than in the general population.
- IADHSS in these patients was consistently associated with either lung pathology or central nervous system (CNS) pathology.
- In one case, IADHSS was observed before the diagnosis of Pneumocystis carinii pneumonitis, suggesting it can be an early indicator.
Impact:
- This study suggests that IADHSS is a significant complication in AIDS patients.
- The findings emphasize the need to suspect IADHSS or adrenal pathology in AIDS patients presenting with hyponatremia.
- Early recognition of IADHSS can aid in timely diagnosis and management of associated conditions in AIDS patients.
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