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Gateways to clinical trials.

M Bayés1, X Rabasseda, J R Prous

  • 1Prous Science, S.A., PO Box 540,08080 Barcelona, Spain. mbayes@prous.com

Methods and Findings in Experimental and Clinical Pharmacology
|September 7, 2007
PubMed
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This study reviews a comprehensive list of investigational drugs and therapeutic agents, including cancer vaccines and novel small molecules, highlighting their potential in various clinical applications and ongoing research efforts.

Area of Science:

  • Pharmacology and Drug Discovery
  • Oncology
  • Immunology

Background:

  • The landscape of pharmaceutical research is continuously evolving with the development of novel therapeutic agents.
  • Numerous small molecules, biologics, and vaccines are under investigation for diverse medical conditions.
  • Identifying and categorizing these investigational agents is crucial for understanding research trends and potential clinical applications.

Purpose of the Study:

  • To compile and present a broad spectrum of investigational drugs and therapeutic agents currently in research and development.
  • To provide an overview of agents targeting various diseases, including cancer, inflammatory conditions, and infectious diseases.
  • To serve as a reference for researchers, clinicians, and industry professionals interested in the current pipeline of novel therapeutics.

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Main Methods:

  • Systematic compilation of drug names and investigational agents from scientific literature and databases.
  • Categorization of agents based on their therapeutic class and primary area of investigation.
  • Inclusion of both small molecule inhibitors and biological therapeutics, such as vaccines and recombinant proteins.

Main Results:

  • The compilation includes a wide array of agents such as ABT-869, Agomelatine, Alvocidib hydrochloride, AMG-386, Arsenic trioxide, Cediranib, Degarelix acetate, Everolimus, Fluticasone furoate, Glucarpidase, Human papillomavirus vaccine, Icatibant acetate, Interleukin-21, Nilotinib, Pemetrexed disodium, Pertuzumab, Recombinant human soluble thrombomodulin, Rubitecan, Seliciclib, Temsirolimus, Ticagrelor, and Tirapazamine.
  • Agents span multiple therapeutic areas including oncology (e.g., Alvocidib hydrochloride, AMG-386, Cediranib, Pertuzumab, Temsirolimus), immunology (e.g., Cancer vaccine, Human papillomavirus vaccine, Mepolizumab), and other indications (e.g., Agomelatine, Ticagrelor).
  • The list encompasses small molecules, antibody-drug conjugates, recombinant proteins, and vaccines, reflecting the diversity of modern drug development.

Conclusions:

  • The extensive list of investigational agents underscores the significant global effort in pharmaceutical research and development.
  • These agents represent diverse mechanisms of action and therapeutic targets, offering potential breakthroughs in treating various diseases.
  • Continued research and clinical evaluation are essential to determine the efficacy and safety of these promising therapeutic candidates.