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Homing of Hematopoietic Cells to the Bone Marrow

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Published on: March 18, 2009

Hematologic values in young pretraining healthy Greyhounds.

Robert E Shiel¹, Sheila F Brennan, Laurie G O'Rourke

¹Small Animal Clinical Studies Unit, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. robert.shiel@ucd.ie

Veterinary Clinical Pathology

|September 7, 2007

Summary

Hematologic values in young Greyhounds differ from adult reference ranges by 9-10 months of age, with younger dogs showing comparable results. These breed-specific differences are not influenced by training.

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Area of Science:

Veterinary Hematology
Canine Physiology

Background:

Greyhounds exhibit unique clinicopathologic and hematologic profiles compared to other breeds.
Factors influencing these differences, such as age, sex, and training, require further investigation.

Purpose of the Study:

To evaluate hematologic values in young, pretraining Greyhounds.
To ascertain the impact of age and sex on these hematologic parameters.

Main Methods:

Blood samples were collected from 43 healthy Greyhounds (5-13 months old).
Hematologic analysis was performed using an Abbott CELL-DYN 3500R analyzer.
Data were analyzed for age and sex correlations and compared to adult canine reference intervals.

Main Results:

Greyhounds aged 9-10 months showed higher HCT, hemoglobin, and RBC counts than adult reference intervals.
Younger Greyhounds (5-6 months) had comparable values.
WBC, neutrophil, lymphocyte, and platelet counts were generally lower than reference ranges.
RBC-related parameters correlated positively with age; platelet count correlated negatively with age.
No significant sex-based differences were observed.

Conclusions:

Significant hematologic differences emerge in Greyhounds by 9-10 months of age, distinct from adult non-breed-specific reference intervals.
These differences are less pronounced in younger Greyhounds (5-6 months).
The findings suggest that training or racing are unlikely causes for the hematologic variations observed in adult Greyhounds.