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Published on: October 24, 2016
Phagocytic plasmacytoma in a dog
Jennifer H Yearley1, Christine Stanton, Thierry Olivry
1Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA. jennifer_yearley@hms.harvard.edu
Veterinary Clinical Pathology
|September 7, 2007
Summary
This study identifies a rare case of plasma cell tumor in a Golden Retriever, highlighting its phagocytic activity. This finding is crucial for differentiating such tumors from histiocytic sarcoma in veterinary oncology.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
- Canine Neoplasia
Background:
- Histiocytic sarcoma is a common malignancy in dogs, often presenting with phagocytic cells.
- Accurate tumor classification is critical for effective treatment and prognosis in veterinary oncology.
Observation:
- A Golden Retriever presented with a forelimb mass initially suspected as histiocytic sarcoma.
- Abdominal ultrasound revealed splenic nodules with highly phagocytic round neoplastic cells.
- Histology of the limb mass showed extensive cytophagia and erythrophagia.
Findings:
- Immunohistochemistry was negative for BLA.36, with sporadic lysozyme and CD79a positivity.
- Immunofluorescence confirmed plasma cell origin with strong immunoglobulin (Ig) G positivity.
- The tumor exhibited significant phagocytic activity, mimicking histiocytic neoplasms.
Implications:
- This case underscores the importance of considering plasma cell origin in phagocytic round cell tumors.
- Accurate diagnosis through advanced techniques like immunofluorescence is vital for challenging cases.
- Understanding differential diagnoses improves treatment strategies for canine cancers.
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