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[In vitro identification of a mononuclear precursor of osteoclast]
B Prallet1, C Alexandre, R Baron
1Laboratoire de Biologie du Tissu Osseux, Université de Médecine, Saint-Etienne.
Abstract:
Osteoclast is derived from mononuclear hematopoietic stem cells, most likely within the granulocyte-macrophage lineage. The exact differentiation process of osteoclasts precurssors has only been partially uncovered. The authors isolated in vitro, from the medullary bone of hens a mononuclear precursor of the osteoclast. This cell expressed several characteristics of mature and multinucleated osteoclast including the capacity to resorb the extracellular bone matrix.
Insights
Researchers isolated a mononuclear osteoclast precursor from hen bone marrow. This precursor cell demonstrated the ability to resorb bone matrix, offering insights into osteoclast differentiation.
Area of Science:
- Cell Biology
- Bone Biology
- Hematopoiesis