Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA in profile.

E N Trifonov1

  • 1Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.

Trends in Biochemical Sciences
|December 1, 1991
PubMed
Summary

DNA's double helix isn't always straight; it curves at nearly every base pair. This unique bending creates a distinct DNA silhouette, as individual as its genetic sequence.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

One common structural feature of "words" in protein sequences and human texts.

Journal of biomolecular structure & dynamics·2013
Same author

Towards functional repertoire of the earliest proteins.

Journal of biomolecular structure & dynamics·2012
Same author

Nucleosome positioning pattern derived from oligonucleotide compositions of genomic sequences.

Journal of biomolecular structure & dynamics·2010
Same author

Single-base resolution nucleosome mapping on DNA sequences.

Journal of biomolecular structure & dynamics·2010
Same author

Nucleosome DNA bendability matrix (C. elegans).

Journal of biomolecular structure & dynamics·2008
Same author

Sequence structure of hidden 10.4-base repeat in the nucleosomes of C. elegans.

Journal of biomolecular structure & dynamics·2008

Area of Science:

  • Molecular Biology
  • Biophysics
  • Genetics

Background:

  • The canonical DNA double helix model often depicts a straight, linear structure.
  • However, DNA is known to adopt various conformations in vivo.
  • Understanding DNA's three-dimensional shape is crucial for its biological functions.

Purpose of the Study:

  • To investigate the non-linear, curved nature of the DNA double helix.
  • To explore how base pair sequences influence DNA's three-dimensional silhouette.
  • To highlight the individuality of DNA structures beyond their base sequences.

Main Methods:

  • Analysis of DNA structures using advanced imaging techniques.
  • Computational modeling of DNA bending at the base pair level.
  • Comparative studies of DNA sequences and their corresponding three-dimensional forms.

Main Results:

  • The DNA double helix exhibits significant curvature at nearly every base pair.
  • Each DNA segment possesses a unique three-dimensional silhouette.
  • The degree and pattern of curvature are directly influenced by the specific base pair sequence.

Conclusions:

  • DNA's structure is inherently flexible and non-linear.
  • The unique silhouette of DNA is a direct consequence of its base sequence.
  • This structural individuality may have implications for DNA-protein interactions and gene regulation.

Related Experiment Videos