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Bioconversions of ergot alkaloids
1Institute of Microbiology, Czechoslovak Academy of Sciences, Prague.
Advances in Biochemical Engineering/Biotechnology
|January 1, 1991
Summary
Bioconversions of ergot alkaloids are increasingly vital for pharmaceutical applications. This study reviews bioconversion methods and potential uses of these important compounds.
Area of Science:
- Biotechnology
- Medicinal Chemistry
- Pharmacology
Background:
- Ergot alkaloids are crucial pharmaceutical compounds with diverse medical applications.
- Industrial-scale bioproduction and subsequent chemical modification are common.
- Bioconversions of ergot alkaloids are gaining significance in recent years.
Purpose of the Study:
- To compile existing data on ergot alkaloid bioconversions.
- To explore the potential applications of these bioconversions.
- To review various bioconversion strategies and their outcomes.
Main Methods:
- Biooxidations and glycosylations of clavines.
- Bioconversions of lysergic acid derivatives.
- Biotransformation of ergot alkaloids in mammalian systems.
- Utilization of immobilized enzyme systems and cofermentation techniques.
Main Results:
- Detailed overview of various ergot alkaloid bioconversion pathways.
- Identification of key metabolites obtained through biotransformation.
- Discussion on the efficiency and scalability of different bioconversion approaches.
- Exploration of novel applications stemming from bioconversion products.
Conclusions:
- Ergot alkaloid bioconversions offer significant potential for pharmaceutical development.
- Diverse bioconversion strategies can yield valuable intermediates and metabolites.
- Further research into immobilized systems and cofermentation can enhance industrial applications.