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Related Experiment Videos

Membrane bioreactors: present and prospects.

H N Chang1, S Furusaki

  • 1Department of Chemical Engineering, Korea Advanced Institute of Science and Technology, Seoul.

Advances in Biochemical Engineering/Biotechnology
|January 1, 1991
PubMed
Summary
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Membrane bioreactors offer in-situ separation, enabling high-density cell cultures and enhanced enzyme activity for increased productivity. These systems show promise for various cell types and industrial applications.

Area of Science:

  • Biotechnology
  • Chemical Engineering
  • Bioprocess Engineering

Background:

  • Traditional bioreactors lack in-situ separation capabilities.
  • Membrane bioreactors integrate membrane separation with biocatalysis.
  • Various systems can be generated by combining membrane functions with biocatalysts like enzymes and cells.

Purpose of the Study:

  • To explore the capabilities and applications of membrane bioreactor systems.
  • To highlight the advantages of membrane bioreactors for cell culture and enzyme reactions.
  • To discuss the potential for expanding industrial applications of membrane bioreactors.

Main Methods:

  • Utilizing the cell-retaining property of membranes for high cell density cultures.
  • Employing selective removal of inhibitory byproducts.

Related Experiment Videos

  • Applying membrane technology to enzyme reactions, anaerobic/aerobic cultures, and animal/plant cell cultures.

    • Main Results:

    • High cell density cultures are achievable due to cell retention and byproduct removal.
    • Improved utilization of enzyme catalytic activity leads to high bioreactor productivity.
    • Membrane bioreactors are advantageous for enzyme reactions involving cofactors and macromolecule hydrolysis.
    • Efficient anaerobic and aerobic cultures are possible using specific membrane bioreactor configurations.
    • Animal and plant cells show increased success rates in membrane reactors.

    Conclusions:

    • Membrane bioreactors offer significant advantages in productivity and cell culture density.
    • Specific configurations are suitable for diverse applications, including enzyme, anaerobic, aerobic, animal, and plant cell cultures.
    • Current industrial use is limited but expected to expand as challenges are addressed.