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Related Experiment Videos

Additive risk factors in atherosclerosis.

F A Kummerow, B H Cho, W Y Huang

    The American Journal of Clinical Nutrition
    |May 1, 1976
    PubMed
    Summary

    High vitamin D levels in animal feed exceed recommendations, potentially impacting swine aorta health. Excess vitamin D3 and added fats/cholesterol in swine diets correlated with increased smooth muscle cell degeneration.

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    Area of Science:

    • Nutritional Science
    • Veterinary Medicine
    • Biochemistry

    Background:

    • Commercial livestock feeds often contain vitamin D3 significantly exceeding National Research Council (NRC) recommendations.
    • High levels of vitamin D activity have been observed in animal tissues from animals consuming these feeds.

    Purpose of the Study:

    • To investigate the impact of high dietary vitamin D3 on swine aorta health.
    • To assess the effects of supplemental fats and cholesterol in combination with high vitamin D3 on swine aorta.

    Main Methods:

    • Comparative analysis of vitamin D levels in human and swine tissues.
    • Feeding trials with weanling swine using a basal ration supplemented with high levels of vitamin D3.
    • Further supplementation of the ration with hydrogenated fat and cholesterol.

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    Main Results:

    • Swine tissues showed high vitamin D activity when fed commercial rations with excessive vitamin D3.
    • Swine fed a high vitamin D3 ration exhibited increased smooth muscle cell degeneration in the aorta compared to those on a standard commercial ration.
    • Further supplementation with hydrogenated fat and cholesterol exacerbated smooth muscle cell degeneration in the aorta.

    Conclusions:

    • Excessive vitamin D3 in swine feed, even within commercially available rations, may negatively affect aorta health.
    • Dietary fat and cholesterol can potentiate the adverse effects of high vitamin D3 on vascular smooth muscle cells.