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[The biological availability of cefadroxil given simultaneously with N-acetylcysteine]
M F Barkworth1, B Mangold, K D Rehm
1Iphar-CRF Institut für Klinische Pharmakologie GmbHa, München.
Arzneimittel-Forschung
|August 1, 1991
Summary
Oral cefadroxil can be taken with n-acetylcysteine. This combination does not alter cefadroxil bioavailability, though sputum concentrations may increase slightly.
Area of Science:
- Pharmacology
- Clinical Pharmacy
Background:
- Cefadroxil is an oral cephalosporin antibiotic.
- N-acetylcysteine is a mucolytic agent.
- Preliminary data suggested co-administration compatibility with other antibiotics.
Purpose of the Study:
- To evaluate the pharmacokinetic profile and bioavailability of cefadroxil when administered alone versus with n-acetylcysteine.
- To assess the safety and efficacy of combining cefadroxil and n-acetylcysteine.
Main Methods:
- A randomized, cross-over study involving 12 healthy male volunteers.
- Administration of single oral doses of 1000 mg cefadroxil or 1000 mg cefadroxil plus 200 mg n-acetylcysteine.
- Plasma and sputum samples analyzed via HPLC for cefadroxil concentrations at defined intervals.
- A one-week wash-out period between study days.
Main Results:
- Cefadroxil bioavailability was bioequivalent when administered alone or in combination with n-acetylcysteine.
- Higher cefadroxil concentrations were observed in sputum when co-administered with n-acetylcysteine, though this difference was not statistically significant.
- No significant changes in cefadroxil pharmacokinetics were noted.
Conclusions:
- Simultaneous administration of oral cefadroxil and n-acetylcysteine is feasible.
- The combination does not negatively impact cefadroxil bioavailability.
- Potential for enhanced cefadroxil penetration into sputum warrants further investigation.