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Effect of an interferon inhibitor on the antiproliferative signal of interferon-alpha
A Aszalos1, K C Chadha, I Stadler
1Division of Research and Testing, Food and Drug Administration, Washington, D.C. 20204.
Abstract:
We have described a nonantibody type inhibitor of interferons (IFN) in the blood of patients with AIDS, advanced neoplastic disorders, and lupus erythematosus in earlier reports (1,2). In the present study we show that the semipurified inhibitor blocks the antiproliferative signal of IFN-alpha in Daudi cells and the membrane potential shifting ability of IFN-alpha is modulated by the interferon inhibitor preparation (IFI).
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