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Differential c-myc protein expression in Burkitt's lymphomas and EBV-transformed lymphoblastoid lines
A D Wennborg1, E Altiok, J P Moore
1Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden.
European Journal of Cancer (Oxford, England : 1990)
|January 1, 1991
Abstract:
The levels of c-myc protein expression in three types of Epstein-Barr virus (EBV) transformed human B-cell derived lines were examined with an ELISA assay. Six independently maintained sublines of the same EBV-transformed pro-B-cell line (FLEB-14), six B-cell lines (LCL) and six Burkitt's lymphoma lines (BL) were compared. The average amount of c-myc protein, calculated from at least three independent tests on each line, differed between the three groups. Expressed in relative units, the ratio of the means was 1:2:5 for the LCL:FLEB:BL lines. The differences were statistically significant at P less than 0.01.