Related Experiment Videos
Synthesis of some 3',5'-dideoxy-5'-C-phosphonomethyl nucleosides
P Ioannidis1, B Classon, B Samuelsson
1Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
Acta Chemica Scandinavica (Copenhagen, Denmark : 1989)
|August 1, 1991
Abstract:
Ammonium [1-(3',5',6'-trideoxy-beta-D-erythro-hexofuranosyl)thymine]-6'- phosphonate (1), ammonium 3',5'-dideoxycytidine-5'-C-methylphosphonate (2) and 3',5'-dideoxyadenosine-5'-C-methyl phosphonic acid (3) have been synthesized and tested for anti-HIV activity. The key steps involved an Arbuzov reaction between triethyl phosphite and 3,5,6-trideoxy-6-iodo-1,2-O-isopropylidene-alpha-D-erythro- hexofuranose (7), followed by condensation with the appropriate nucleoside bases. The substances 1, 2 and 3 have been tested in vitro against HIV.