Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Super-resolution Fluorescence Microscopy

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been developed.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

National Diagnostic Working Group (NDWG) for inertial confinement fusion (ICF)/high-energy density (HED) science: The whole exceeds the sum of its parts.

The Review of scientific instruments·2023

Same author

The dilation aided single-line-of-sight x-ray camera for the National Ignition Facility: Characterization and fielding.

The Review of scientific instruments·2018

Same author

Time resolved detection of two-plasmon decay using three-halves harmonic emission on the National Ignition Facility.

The Review of scientific instruments·2018

Same author

Superconductivity in HfTe<sub>5</sub> across weak to strong topological insulator transition induced via pressures.

Scientific reports·2017

Same author

Superconductivity Bordering Rashba Type Topological Transition.

Scientific reports·2017

Same author

A high-speed two-frame, 1-2 ns gated X-ray CMOS imager used as a hohlraum diagnostic on the National Ignition Facility (invited).

The Review of scientific instruments·2016

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

High-Sensitivity Nuclear Magnetic Resonance at Giga-Pascal Pressures: A New Tool for Probing Electronic and Chemical Properties of Condensed Matter under Extreme Conditions

High-Sensitivity Nuclear Magnetic Resonance at Giga-Pascal Pressures: A New Tool for Probing Electronic and Chemical Properties of Condensed Matter under Extreme Conditions

Published on: October 10, 2014

Ultrahigh pressure: beyond 2 megabars and the ruby fluorescence scale.

P M Bell, H K Mao, K Goettel

Science (New York, N.Y.)

|November 2, 1984

Summary

Researchers developed a novel diamond-window, high-pressure cell, achieving a record static pressure of 2.8 megabars. This stable design enables the study of materials, including hydrogen, at unprecedented pressures above 1 megabar.

Area of Science:

Materials Science
High-Pressure Physics
Geophysics

Background:

High-pressure research is crucial for understanding planetary interiors and material properties.
Previous high-pressure cells faced limitations in achievable pressures and mechanical stability.
Exploring pressures above 1 megabar is essential for discovering novel material phases.

Purpose of the Study:

To introduce a new diamond-window, high-pressure cell design.
To demonstrate the generation of static pressures exceeding 1 megabar.
To enable the study of materials under extreme static pressures.

Main Methods:

Development of a mechanically stable diamond-window, high-pressure cell.
Static pressure generation and measurement techniques.

More Related Videos

High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States

High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States

Published on: June 29, 2021

$Synthesis and Microdiffraction at Extreme Pressures and Temperatures$

Synthesis and Microdiffraction at Extreme Pressures and Temperatures

Published on: October 7, 2013

Related Experiment Videos

Last Updated: Jul 11, 2026

High-Sensitivity Nuclear Magnetic Resonance at Giga-Pascal Pressures: A New Tool for Probing Electronic and Chemical Properties of Condensed Matter under Extreme Conditions

High-Sensitivity Nuclear Magnetic Resonance at Giga-Pascal Pressures: A New Tool for Probing Electronic and Chemical Properties of Condensed Matter under Extreme Conditions

Published on: October 10, 2014

High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States

High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States

Published on: June 29, 2021

$Synthesis and Microdiffraction at Extreme Pressures and Temperatures$

Synthesis and Microdiffraction at Extreme Pressures and Temperatures

Published on: October 7, 2013

Material analysis under high-pressure conditions.

Main Results:

Achieved a static pressure of 2.8 megabars for the first time.
The new cell design exhibits unusual mechanical stability.
The cell is suitable for studying diverse materials, including hydrogen.

Conclusions:

The novel high-pressure cell design overcomes previous limitations.
Static pressures of 2.8 megabars are now attainable.
This advancement opens new avenues for materials research in the unexplored megabar pressure region.