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Updated: Jul 11, 2026

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Published on: March 8, 2024
Benzaldehyde derivatives from Sarcodontia crocea.
Tetsuo Kokubun1, Zbigniew Rozwadowski, Helmut Duddeck
1Jodrell Laboratory, Royal Botanic Gardens, Richmond, Surrey, UK. t.kokubun@kew.org
Two novel benzaldehyde derivatives were isolated from the fungus Sarcodontia crosea. These compounds contribute to the fungus
Area of Science:
- Natural Product Chemistry
- Mycology
- Organic Chemistry
Background:
- The Basidiomycete Sarcodontia crosea (syn. S. setosa) possesses a distinct odor.
- Volatile compounds are crucial for fungal identification and ecological interactions.
Purpose of the Study:
- To isolate and characterize volatile compounds from Sarcodontia crosea.
- To investigate the potential bioactivity of isolated compounds.
Main Methods:
- Bioactivity-guided fractionation of fungal extracts.
- Structure elucidation using 2D Nuclear Magnetic Resonance (NMR) techniques.
- Microdilution assays for antifungal and antibacterial activity screening.
Main Results:
- Two benzaldehyde derivatives, 4-(furan-3-yl)benzaldehyde (1) and 4-(5-oxotetrahydrofuran-3-yl)benzaldehyde (2), were isolated.
- Compound 1 is a new natural product; compound 2 was previously synthesized.
- Isolated compounds exhibited weak antifungal activity against phytopathogenic fungi and lower potency against bacteria.
Conclusions:
- The identified benzaldehyde derivatives likely contribute to the characteristic odor of Sarcodontia crosea.
- The compounds possess limited antifungal and antibacterial properties.
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