Prognostic factors in stage-i (T1N0) breast carcinoma patients: who needs adjuvant systemic treatment?

There is no consensus about the need of adjuvant therapy in T(1)N(0) breast carcinoma patients. To select a subgroup of these patients who may benefit from adjuvant systemic therapy, prognostic factor analyses were carried out using chi-square test and Cox regression analysis in 187 patients data in this retrospective study. Primary endpoint was distant metastasis (DM). The multivariate Cox analysis showed that age group (35 years, p=0.01; Hazard Ratio [HR], 15.4; 95% Confidence Interval [CI], 1.8-133.0), tumor size (>1 cm vs