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Wade's histoid leprosy: three clinical presentations.
Susana B Pereyra1, Cristián A Danielo, Gustavo J Ponssa
1Departments of Dermatology and Pathology, Hospital Córdoba, Córdoba, Argentina.
International Journal of Dermatology
|September 8, 2007
Summary
Wade's histoid leprosy, a rare multibacillary leprosy variant, can present initially with distinctive skin nodules. This case series details three patients with this rare form, highlighting their clinical and histological features.
Area of Science:
- Dermatology
- Infectious Diseases
- Pathology
Background:
- Wade's histoid leprosy is a rare, distinct form of multibacillary leprosy.
- It can manifest as relapse, sulfone resistance, or de novo presentation.
- This variant was first described in patients treated with short-course sulfones.
Observation:
- Three adult male patients with initial presentation of Wade's histoid leprosy were observed.
- Two patients were from a leprosy-endemic area.
- All presented with firm, elastic, erythematous to brownish-gray nodules on the extremities.
Findings:
- The study details the clinical, histologic, immunologic, and bacteriologic features of these patients.
- Histoid leprosy presented as the initial manifestation of lepromatous leprosy.
- Patients responded well to standard multibacillary leprosy treatment without reactional episodes.
Implications:
- This report expands the understanding of Wade's histoid leprosy as an initial presentation.
- It underscores the importance of recognizing this rare variant in endemic and non-endemic areas.
- Early diagnosis and appropriate treatment are crucial for managing this leprosy subtype.
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