Related Experiment Video
Updated: Jul 11, 2026

06:06
Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Total joint arthroplasty: the final solution for knee and hip when synovitis could not be controlled
1Department of Orthopaedics and Haemophilia Unit, La Paz University Hospital, Madrid, Spain. rmerchan@arrakis.es
Summary
Total hip and knee arthroplasty can improve function in severe haemophilic arthropathy patients. Despite surgical challenges and potential complications, this procedure offers a valuable treatment option for managing joint pain and functional deficits.
Area of Science:
- Orthopedic Surgery
- Hematology
- Rheumatology
Background:
- Haemophilic arthropathy frequently affects the knee and hip joints in severe cases.
- This condition causes significant pain and functional impairment, impacting patients' quality of life.
Purpose of the Study:
- To review the functional outcomes of hip and knee arthroplasty in patients with haemophilic arthropathy.
- To assess postoperative and long-term complications associated with these procedures.
- To evaluate the impact of Human Immunodeficiency Virus (HIV) on arthroplasty outcomes in this patient group.
Main Methods:
- Literature review of functional outcomes, complications, and HIV impact.
- Analysis of surgical management including total knee and hip arthroplasty.
- Synthesis of findings from the author's experience and existing studies.
Main Results:
- Arthroplasty, while technically demanding, demonstrates positive functional outcomes for severe haemophilic arthropathy.
- Common complications are described, necessitating careful surgical planning and management.
- The impact of HIV requires consideration in the overall assessment of surgical risks and benefits.
Conclusions:
- Hip and knee arthroplasty are viable and valuable treatment options for severe haemophilic arthropathy when conservative methods fail.
- Careful patient selection and management are crucial to optimize results and mitigate risks.
- Further research may explore specific strategies to minimize complications in this complex patient population.
Related Concept Videos
Knee Joint
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
Development of the Limb Synovial Joints
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Structural Joints: Synovial Joints
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
Ankle Joint
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...