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Published on: May 31, 2016
Long-term outcome of 50 consecutive Parkinson's disease patients treated with subthalamic deep brain stimulation
1Department of Neurology, CHUV, Rue du Bugnon, 1011 Lausanne, Switzerland.
Objective:
To describe the long-term outcome in 50 consecutive advanced Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS).
Method:
Assessments were carried out at baseline, 6 months, 2 years, and 5 years postoperatively.
Results:
Compared to baseline scores without medication, we found a highly significant improvement of UPDRS III with stimulation, maintained at 5 years (p<0.001). This improvement, however, tended to diminish over time. Dyskinesia and off periods were also improved (p<0.0001 for both). Seventeen patients died during follow-up, who tended to be older at surgery (p<0.01).
Conclusions:
STN-DBS is an effective treatment for advanced PD patients, and the beneficial effect is maintained at 5 years. However, worsening occurs over time due to disease progression.
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