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Store-operated Ca2+ entry and TRPC expression; possible roles in cardiac pacemaker tissue

Yue-kun Ju1, David G Allen

  • 1School of Medical Sciences (F13), University of Sydney, Sydney, NSW 2006, Australia. ju@physio.usyd.edu.au

Heart, Lung & Circulation
|September 8, 2007
PubMed
Summary

Store-operated calcium channels (SOCCs), potentially linked to TRPC proteins, may influence cardiac pacemaking. Evidence suggests SR calcium store depletion can trigger calcium entry, impacting pacemaker current and heart rate.

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