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Related Experiment Video

Updated: Jul 11, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse

A Periprosthetic Joint Candida albicans Infection Model in Mouse

Published on: February 2, 2024

Does "excessive" anticoagulation predispose to periprosthetic infection?

Javad Parvizi¹, Elie Ghanem, Ashish Joshi

¹Rothman Institute of Orthopedics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

The Journal of Arthroplasty

|October 11, 2007

Summary

Excessive anticoagulation may increase periprosthetic infection risk. Careful management of anticoagulation is crucial to prevent hematoma and drainage, thereby reducing infection after joint replacement surgery.

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Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

Area of Science:

Orthopedic Surgery
Infectious Disease

Background:

Periprosthetic infection is a serious complication following joint replacement.
Persistent drainage and hematoma are known risk factors for infection.

Purpose of the Study:

To investigate if excessive anticoagulation is a predisposing factor for periprosthetic infection.
To identify risk factors for developing periprosthetic infection after joint revision surgery.

Main Methods:

A 2:1 case-control study involving 78 cases undergoing revision for septic failure.
Comparison of patient comorbidities, medications, and intraoperative/postoperative factors between infected cases and uninfected controls.

Main Results:

Postoperative wound complications, including hematoma and drainage, were significant risk factors for infection.
A mean international normalized ratio (INR) > 1.5 was more prevalent in patients who developed wound complications and subsequent periprosthetic infection.

Conclusions:

Excessive anticoagulation may contribute to periprosthetic infection by increasing the risk of hematoma and drainage.
Cautious anticoagulation management is critical to prevent periprosthetic infection and its complications.