Related Experiment Video
Updated: Jul 11, 2026

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
Published on: December 26, 2016
The effect of miswak extract on plaque pH. An in vivo study
A Sofrata1, P Lingström, M Baljoon
1Department of Periodontology, Institute of Odontology, Karolinska Institutet, Stockholm, Sweden. abier.sofrata@ki.se
Abstract:
The aim of this study was to document changes in plaque pH when an acidic challenge was followed by rinsing with miswak extract (Salvadora persica), and to evaluate the effect of miswak rinse on parotid gland secretion rate. Plaque pH was measured in 3-day-old plaque using the microtouch electrode. Rinsing with miswak extract, compared with water rinsing, resulted in protracted elevation of plaque pH (>6.0). The difference in plaque pH between miswak extract and water rinse was statistically significant at 30 min (p < 0.001). Rinsing with miswak extract stimulated parotid gland secretion (p < 0.01). In conclusion, miswak extract raised the plaque pH, suggesting a potential role in caries prevention.
Insights
Miswak extract (Salvadora persica) significantly elevates plaque pH after an acidic challenge, compared to water. This natural rinse also stimulates salivary secretion, indicating potential for dental caries prevention.
Area of Science:
- Oral health research
- Natural product chemistry
- Dental hygiene
Background:
- Dental caries is a prevalent oral disease.
- Maintaining optimal plaque pH is crucial for preventing demineralization.
- Miswak (Salvadora persica) is a traditional chewing stick used for oral hygiene.
Purpose of the Study:
- To investigate the effect of miswak extract rinse on plaque pH following an acidic challenge.
- To assess the impact of miswak extract on parotid gland secretion rate.
Main Methods:
- Plaque pH was measured using a microtouch electrode in 3-day-old plaque.
- Participants rinsed with either miswak extract or water after an acidic challenge.
- Parotid gland secretion rate was monitored.
Main Results:
- Miswak extract rinse led to a sustained elevation of plaque pH above 6.0.
- The increase in plaque pH with miswak extract was statistically significant compared to water at 30 minutes (p < 0.001).
- Miswak extract significantly stimulated parotid gland secretion (p < 0.01).
Conclusions:
- Miswak extract demonstrates a significant acid-buffering capacity in plaque.
- The stimulation of salivary secretion by miswak extract may contribute to its oral health benefits.
- Miswak extract shows promise as a natural agent for dental caries prevention.

