Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Topographical requirements for delta-selective opioid peptides.

G V Nikiforovich1, V J Hruby, O Prakash

  • 1Department of Chemistry, University of Arizona, Tucson 85721.

Biopolymers
|July 1, 1991
PubMed
Summary

Energy calculations reveal a specific spatial arrangement for delta-selective opioid peptides bound to receptors. This model accurately predicts the positioning of key side chains, aiding in the design of novel analgesics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A phase II, randomized, open-label study to evaluate low-dose pembrolizumab plus chemotherapy versus chemotherapy as neoadjuvant therapy for localized triple-negative breast cancer (TNBC) (PLANeT trial-Pembrolizumab Low dose in Addition to NACT in TNBC).

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Fabrication and analysis of enhanced thermal stability and high-sensitivity turnaround point long-period fiber grating.

Applied optics·2022
Same author

A Comparative Study of Enriched Culture Media and Selective Culture in the Diagnosis of Gonorrhoea.

Indian journal of dermatology and venereology·2017
Same author

Caregiver burden in Alzheimer-type dementia and psychosis: A comparative study from India.

Asian journal of psychiatry·2017
Same author

Flow and thermal characteristics of high Reynolds number (2800-17,000) dye cell: simulation and experiment.

Applied optics·2015
Same author

Predominance of modern Mycobacterium tuberculosis isolates in North India.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2014

Area of Science:

  • Molecular modeling
  • Computational chemistry
  • Pharmacology

Background:

  • Opioid peptides interact with specific receptors, influencing pain perception.
  • Understanding the conformational dynamics of these peptides is crucial for drug design.
  • Delta-selective opioid peptides like DPDPE, DCFPE, and dermenkephalin (DRE) are targets for analgesic development.

Purpose of the Study:

  • To explore the conformational possibilities of three delta-selective opioid peptides using computational methods.
  • To develop a model for the receptor-bound conformer(s) of these peptides.
  • To correlate computational findings with existing biological testing data.

Main Methods:

  • Energy calculations were performed on DPDPE, DCFPE, and DRE to identify low-energy conformers.

Related Experiment Videos

  • Geometrical shapes of conformers were compared using topographical analysis.
  • The spatial arrangement of N-terminal amino and Tyr/Phe side-chain groups was examined.

    • Main Results:

    • Extensive sets of low-energy conformers were generated for each peptide (61 for DPDPE, 32 for DCFPE, 38 for DRE).
    • A model for delta-receptor-bound conformers was proposed, specifying Phe side-chain placement.
    • The Tyr1 side chain's position was less precisely determined, but the model aligned with biological data.

    Conclusions:

    • The study provides a structural model for delta-opioid peptide-receptor interactions.
    • The proposed model accurately predicts side-chain positioning, particularly for Phe.
    • This research facilitates the rational design of more effective and selective opioid-based therapeutics.