Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Assessment of Airway, Skin Color, and Use of Accessory Muscles

Assessment of Airway, Skin Color, and Use of Accessory Muscles

A thorough assessment of respiratory health is paramount in clinical settings to identify and manage respiratory distress and ensure adequate oxygenation. This article elaborates on the critical aspects of respiratory evaluation, including airway assessment, skin color examination, and the observation of accessory muscle use, which are integral to effectively diagnosing and managing patients with respiratory conditions.
Introduction
The initial evaluation of a patient's respiratory system...

Factors Affecting Pulmonary Ventilation

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low tidal volume ventilation facilitates spontaneous increase in bronchoconstriction and air trapping that can be resolved by deep inspiration and bronchodilator.

American journal of physiology. Lung cellular and molecular physiology·2025

Same author

Characteristics of lung resistance and elastance associated with tracheal stenosis and intrapulmonary airway narrowing in ex vivo sheep lungs.

Respiratory research·2024

Same author

Serum Response Factor Overexpression, a Double Trouble that May Underlie Airway Hyperresponsiveness in Asthma.

American journal of respiratory cell and molecular biology·2024

Same author

Rho-Kinase Inhibition of Active Force and Passive Tension in Airway Smooth Muscle: A Strategy for Treating Airway Hyperresponsiveness in Asthma.

Biology·2024

Same author

Critical roles of airway smooth muscle in mediating deep-inspiration-induced bronchodilation: a big stretch?

Respiratory research·2023

Same author

Potentiation of active force by cyclic strain in sheep carotid arterial smooth muscle.

Journal of applied physiology (Bethesda, Md. : 1985)·2023

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

Structural basis for exaggerated airway narrowing.

Peter D Paré¹, Brent E McParland, Chun Y Seow

¹Department of Medicine and Respiratory Division and The James Hogg iCAPTURE Centre, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada. ppare@mrl.ubc.ca

Canadian Journal of Physiology and Pharmacology

|September 8, 2007

Summary

This summary is machine-generated.

Airway hyperresponsiveness in asthma is linked to structural airway remodeling. These changes in airway wall composition and organization contribute to excessive airway narrowing and asthma symptoms.

More Related Videos

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

The Rigid Tube as an Alternative in Controlling the Problematic Airway

The Rigid Tube as an Alternative in Controlling the Problematic Airway

Published on: June 6, 2020

Related Experiment Videos

Last Updated: Jul 11, 2026

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Published on: May 15, 2013

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

The Rigid Tube as an Alternative in Controlling the Problematic Airway

The Rigid Tube as an Alternative in Controlling the Problematic Airway

Published on: June 6, 2020

Area of Science:

Pulmonary Medicine
Respiratory Physiology
Pathology

Background:

Airway hyperresponsiveness is a hallmark of asthma, leading to excessive airway narrowing.
While smooth muscle alterations play a role, structural airway remodeling is also implicated.

Purpose of the Study:

To review quantitative changes in airway wall dimensions and organization in asthma.
To explain how structural alterations contribute to exaggerated airway narrowing.

Main Methods:

Review of existing literature on airway remodeling in asthma.
Analysis of structural changes in airway wall compartments.

Main Results:

Airway remodeling involves changes in the composition, quantity, and organization of airway wall constituents.
Quantitative alterations in airway wall compartments can lead to functional changes.
Modified biochemical composition or material properties of airway wall constituents also contribute.

Conclusions:

Structural changes in the airway wall (remodeling) are a significant factor in asthma.
Airway remodeling can explain the exaggerated airway narrowing observed in asthmatic individuals.