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Updated: Jul 11, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
[Cisplatin ototoxicity: series of cases]
Luiz Alberto Alves Mota1, Marília Silvino Iglésias Melo, Maria Heloísa Pedrosa Santos
1Hospital Universitário Oswaldo Cruz. luizmota10@hotmail.com
Objective:
To evaluate the clinic and audiometric evolution of individuals who underwent chemotherapy with cisplatin.
Methods:
Four volunteers, all women, between 38 and 69 years of age were descriptively evaluated. All did otorinolaryngoiatric exam and audiometric evaluation with tonal and speech audiometric and impedance tests before and after treatment with cisplatin. In addition, all were subjectively evaluated pre- and post-chemotherapy by a questionnaire.
Results:
One volunteer did not present auditory disorders. Three volunteers presented bilateral hearing loss, mild to moderate in 6 kHz and 8 kHz frequencies, after chemotherapy with cisplatin. All volunteers who developed hearing loss after treatment also presented tinnitus.
Conclusion:
Since cisplatin is considered ototoxic, all individuals undergoing chemotherapy with this drug must be submitted to audiometric monitoring for early diagnosis of a hearing loss.

