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Unusual occurrence of allergic bronchopulmonary aspergillosis in a family

Girish Sindhwani1, J Rawat

  • 1Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Dehradun 248140.

Journal of the Indian Medical Association
|September 11, 2007
PubMed

Insights

Familial allergic bronchopulmonary aspergillosis is rare. This report details two cases in siblings, successfully treated with prednisolone, highlighting the need for family screening in asthma patients.

Area of Science:

  • Pulmonology
  • Allergy and Immunology
  • Medical Genetics

Background:

  • Allergic bronchopulmonary aspergillosis (ABPA) is a recognized complication in patients with asthma.
  • While bronchial asthma often exhibits familial clustering, familial occurrences of ABPA are infrequently reported.
  • This underscores a potential gap in understanding the genetic or environmental factors contributing to ABPA.

Observation:

  • Two cases of allergic bronchopulmonary aspergillosis were identified within the same family, specifically a brother and sister.
  • Both patients presented with symptoms consistent with ABPA.
  • This familial clustering suggests a possible shared predisposition or exposure.

Findings:

  • Treatment with prednisolone resulted in complete remission for both affected siblings.
  • The successful outcome demonstrates the efficacy of corticosteroid therapy in managing ABPA.
  • This case series provides evidence for the effectiveness of established treatment protocols.

Implications:

  • Clinicians should maintain a high index of suspicion for ABPA in patients with a history of asthma or rhinitis.
  • Investigating all family members of a diagnosed ABPA patient is crucial, especially if they have a history of asthma or rhinitis.
  • Early diagnosis and treatment of familial ABPA cases can lead to improved patient outcomes and potentially prevent disease progression.

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