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Related Experiment Videos

Apparent polycythaemia.

T C Pearson1

  • 1Department of Haematology, St Thomas' Hospital, London, UK.

Blood Reviews
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Apparent polycythaemia, indicated by elevated packed cell volume (PCV), is often due to normal variations in red cell mass and plasma volume. Management focuses on addressing underlying causes and vascular occlusion risks.

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Area of Science:

  • Hematology
  • Internal Medicine
  • Vascular Medicine

Background:

  • Apparent polycythaemia is defined by elevated packed cell volume (PCV) but normal red cell mass (RCM).
  • Accurate RCM and plasma volume (PV) prediction requires height and weight, not just body weight.
  • A significant proportion of patients with PCV up to 0.60 have normal RCM and PV.

Purpose of the Study:

  • To clarify the causes and clinical associations of apparent polycythaemia.
  • To evaluate the risk of vascular occlusion in patients with apparent polycythaemia.
  • To propose management strategies for apparent polycythaemia.

Main Methods:

  • Analysis of patient data characterized by raised PCV and normal RCM.
  • Review of clinical associations and potential causes of altered RCM/PV.

Related Experiment Videos

  • Assessment of retrospective studies on vascular occlusion risk.

    • Main Results:

    • The most frequent cause of raised PCV is a shift in RCM and/or PV within normal ranges.
    • Clinical associations include obesity, dehydration, smoking, hypertension, and alcohol consumption.
    • An increased risk of vascular occlusion is suggested, influenced by factors like hypertension and smoking.

    Conclusions:

    • Management should involve modifying underlying causes and assessing vascular occlusion risk factors.
    • Venesection is recommended for PCV chronically above 0.54, and for lower PCV if vascular risk is high.
    • The target PCV for venesected patients is 0.45 or below.