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Updated: Jul 11, 2026
09:55
An In Vivo Murine Sciatic Nerve Model of Perineural Invasion
Published on: April 23, 2018
Intraneural perineurioma: a systematic review with illustrative cases
Bobby L Boyanton1, John K Jones, Saleh M Shenaq
1Department of Clinical Pathology, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073, USA. bobby.boyanton@beaumont.edu
Archives of Pathology & Laboratory Medicine
|September 11, 2007
Summary
Intraneural perineurioma is a benign peripheral nerve sheath tumor arising from perineurial cells. It is distinct from Schwann cell tumors and does not recur or metastasize.
Area of Science:
- Neuropathology
- Oncology
- Peripheral Nerve Disorders
Background:
- Intraneural perineurioma shares features with other "onion bulb" Schwann cell lesions, complicating diagnosis.
- Distinguishing perineurial from Schwann cells requires advanced techniques like ultrastructure and immunohistochemistry.
Observation:
- A systematic review of intraneural perineurioma cases was conducted.
- Two illustrative cases from Baylor College of Medicine-affiliated hospitals were included.
- Inclusion criteria involved characteristic histology and confirmed perineurial cell lineage via immunohistochemistry or ultrastructural analysis.
Findings:
- Intraneural perineurioma is a neoplastic proliferation of perineurial cells.
- It exhibits distinct immunohistochemical (epithelial membrane antigen positive, S100 protein negative) and ultrastructural features.
- Despite chromosome 22 abnormalities, it is not associated with neurofibromatosis.
Implications:
- Accurate diagnosis of intraneural perineurioma is crucial to differentiate it from mimickers.
- Understanding its unique features aids in appropriate patient management.
- Intraneural perineurioma is a benign tumor with no recurrence or metastasis.
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