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A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
Published on: October 14, 2016
Acute myeloid leukaemia presenting as galactorrhoea
1Department of Clinical Haematology and Bone Marrow Transplantation, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia. almuslahimnr@hotmail.com
International Journal of Laboratory Hematology
|September 11, 2007
Summary
A woman with acute myeloid leukemia (AML) experienced elevated prolactin levels and galactorrhea. Her prolactin normalized after chemotherapy, suggesting a paraneoplastic phenomenon.
Area of Science:
- Hematology
- Endocrinology
- Oncology
Background:
- Acute myeloid leukemia (AML) presents with diverse clinical symptoms.
- Hyperprolactinemia, characterized by elevated prolactin levels, can have various causes.
Purpose of the Study:
- To report a rare case of acute myeloid leukemia presenting with hyperprolactinemia.
- To explore the potential paraneoplastic link between AML and elevated prolactin.
Main Methods:
- Case report of a 40-year-old female patient.
- Clinical presentation, laboratory findings (including prolactin levels), and treatment response were analyzed.
Main Results:
- The patient presented with galactorrhea and elevated prolactin, despite normal blood counts.
- Acute myeloid leukemia with monocytic differentiation was diagnosed.
- Serum prolactin normalized following chemotherapy.
Conclusions:
- Hyperprolactinemia can be an unusual presenting sign of acute myeloid leukemia.
- The elevated prolactin in this case is presumed to be a paraneoplastic phenomenon in the absence of central nervous system involvement.
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