Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Malaria

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

Vaccinations

Vaccinations

Vaccines

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...

Yellow Fever

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

Poliomyelitis

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exposing the hidden: establishing immunity to Plasmodium liver stage infection.

Trends in parasitology·2025

Same author

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission-blocking target.

FEBS letters·2025

Same author

Stage-dependent expression and vacuolar localization of Plasmodium berghei chloroquine resistance transporter (CRT).

Molecular and biochemical parasitology·2025

Same author

Complete attenuation of Plasmodium falciparum sporozoites by atovaquone-proguanil.

EMBO molecular medicine·2025

Same author

Negative Perception of Bats, Exacerbated by the SARS-CoV-2 Pandemic, May Hinder Bat Conservation in Northern Uganda.

Sustainability·2025

Same author

Red pulp macrophages clear parasites, while marginal metallophilic and marginal zone macrophages support CD4<sup>+</sup> T cell activation during <i>Plasmodium yoelii</i> infection.

Frontiers in immunology·2025

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

Vaccines against malaria - an update.

Kai Matuschewski¹, Ann-Kristin Mueller

¹Department of Parasitology, Heidelberg University School of Medicine, Germany. Kai.Matuschewski@med.uni-heidelberg.de

The FEBS Journal

|September 11, 2007

Summary

Malaria vaccine research explores subunit vaccines and experimental models like live parasites. Experimental models show superior immune responses, offering hope for effective malaria prevention.

Area of Science:

Immunology
Vaccinology
Parasitology

Background:

Malaria remains a significant global health challenge, necessitating effective vaccines.
Current vaccine development primarily focuses on two main strategies.
Naturally acquired immunity develops slowly through prolonged Plasmodium exposure.

Purpose of the Study:

To discuss the different strategies for malaria vaccine discovery and development.
To compare the efficacy of subunit vaccines versus experimental model vaccines.
To outline the potential and challenges in creating an affordable malaria vaccine.

Main Methods:

Review of existing malaria vaccine research and development strategies.
Analysis of subunit vaccine approaches mimicking natural immunity.

More Related Videos

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Published on: August 6, 2020

Related Experiment Videos

Last Updated: Jul 11, 2026

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Measuring Naturally Acquired Phagocytosis-Inducing Antibodies to Plasmodium falciparum Parasites by a Flow Cytometry-Based Assay

Published on: August 6, 2020

Evaluation of experimental models including attenuated live parasites and transmission-blocking antigens.

Main Results:

Subunit vaccines aim to replicate immunity gained over time from Plasmodium exposure.
Experimental vaccines, such as live attenuated parasites, elicit stronger immune responses.
Both approaches present unique advantages and obstacles for malaria vaccine development.

Conclusions:

Experimental malaria vaccine models demonstrate potential for superior immunogenicity.
Further research is needed to overcome hurdles for an effective and affordable malaria vaccine.
Diverse strategies are crucial for advancing malaria prevention globally.