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Updated: Jul 11, 2026

Isolation and Identification of Limbal Niche Cells
Published on: October 27, 2023
Multipotent mesenchymal stem cells from adult human eye conjunctiva stromal cells
Samad Nadri1, Masoud Soleimani, Jafar Kiani
1Stem Cell Department, Stem Cell Technology Co. Ltd, Tehran, Iran.
Abstract:
Identification of mesenchymal stem cells (MSCs) derived from alternative sources has provided an exciting prospect for intensive investigation. This work focused on characterizing a new source of MSCs from stromal cells from human eye conjunctiva. In this study, after conjunctiva biopsies and culture of stromal segment of this tissue, fibroblast-like (SH2+, SH3+, CD29+, CD44+, CD166+, CD13+) human stromal cells, which can be differentiated toward the osteogenic, adipogenic, chondrogenic, and neurogenic lineages, were obtained. These cells expressed Oct-4, Nanog, Rex-1 genes, and some lineage-specific markers like cardiac actin and Keratin. Taken together, the results indicate that conjunctiva stromal-derived cells are a new source of multipotent MSCs and despite originating from an adult source, they express undifferentiated stem cell markers.
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