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Updated: Jul 11, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
Published on: March 17, 2023
The allosteric modulation of lipases and its possible biological relevance
1Institut für Pharmazeutische und Medizinische Chemie, Westfälische Wilhelms-Universität Münster, Hittorfstrasse 58-62, D-48149 Münster, Germany. jenskoeh@uni-muenster.de
Background:
During the development of an enantioselective synthesis using the lipase from Mucor miehei an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown.
Theory:
Considering the biological relevance of the discovered regulation mechanism we developed a theory that describes the regulation of energy homeostasis and fat metabolism.
Conclusion:
This theory represents a new approach to explain the cause of the metabolic syndrome and provides an innovative basis for further research activity.
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