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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Human exposure to bisphenol A (BPA).

Laura N Vandenberg¹, Russ Hauser, Michele Marcus

¹Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA. laura.vandenberg@tufts.edu

Reproductive Toxicology (Elmsford, N.Y.)

|September 11, 2007

Summary

Bisphenol A (BPA), a common plastic chemical, is found in human tissues at levels potentially impacting health. Exposure assessment and metabolism studies are reviewed, highlighting concerns.

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Area of Science:

Environmental Chemistry
Toxicology
Public Health

Background:

Bisphenol A (BPA) is a high-production-volume chemical used in polycarbonate plastics and epoxy resins.
BPA is prevalent in numerous consumer products, leading to widespread human exposure.

Purpose of the Study:

To review and synthesize current knowledge on BPA levels in human tissues and fluids.
To examine epidemiological studies linking BPA exposure to health outcomes.
To assess BPA release from products and environmental presence, and review metabolic data.

Main Methods:

Literature review of studies on BPA levels in humans, products, and the environment.
Analysis of epidemiological data on BPA exposure biomarkers and health effects.
Review of in vitro, animal, and human metabolic studies of BPA.

Main Results:

Human exposure levels in fluids are often higher than in vitro effective concentrations.
BPA levels are comparable to those inducing effects in animal models.
Data on epidemiological links and human metabolism are limited but growing.

Conclusions:

Human exposure to BPA is significant and warrants further investigation.
Current exposure levels may pose a risk, necessitating continued research into health impacts.
Comprehensive assessment of BPA's environmental presence and biological effects is crucial.