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Systemic inflammation in non-obese children with obstructive sleep apnea
David Gozal1, Laura D Serpero, Oscar Sans Capdevila
1Division of Pediatric Sleep Medicine and Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, 570 South Preston Street, Suite 204, Louisville, KY 40202, USA. david.gozal@louisville.edu
Sleep Medicine
|September 11, 2007
Summary
Obstructive sleep apnea (OSA) in children causes inflammation, indicated by higher IL-6 and lower IL-10 levels. Treatment with tonsillectomy and adenoidectomy (T&A) reverses these inflammatory markers.
Area of Science:
- Pediatric sleep medicine
- Immunology
- Cardiovascular health
Background:
- Obstructive sleep apnea (OSA) is linked to systemic inflammation, increasing end-organ damage risk.
- The roles of IL-6 and IL-10 in OSA-related atherogenesis are not well-studied in children.
- Inflammatory cytokine changes in pediatric OSA require further investigation.
Purpose of the Study:
- To assess Interleukin-6 (IL-6) and Interleukin-10 (IL-10) levels in non-obese children with OSA.
- To determine if these inflammatory markers change after tonsillectomy and adenoidectomy (T&A).
Main Methods:
- Polysomnography diagnosed OSA in children aged 4-9 years.
- Plasma IL-6 and IL-10 levels were measured before and after T&A in OSA patients.
- Matched controls without OSA were used for comparison.
Main Results:
- Children with OSA exhibited elevated IL-6 and reduced IL-10 levels compared to controls.
- Post-T&A, IL-6 and IL-10 levels in OSA patients normalized to control levels.
- Inflammation associated with pediatric OSA is present even without obesity.
Conclusions:
- Systemic inflammation is a key feature of pediatric OSA, even in non-obese children.
- Inflammation in pediatric OSA is largely reversible following T&A.
- Treating OSA can mitigate associated inflammatory processes and potential long-term complications.
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