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Published on: December 20, 2024
Elution and mechanical properties of antifungal bone cement
Ben Goss1, Carmen Lutton, Patrick Weinrauch
1AO Spine Reference Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Abstract:
The effect of the incorporation of amphotericin B into bone cement was examined; as literature suggests, this may be a feasible method for the treatment of periprosthetic fungal infections. Addition of antifungal increased the compressive strength of the bone cement--a statistically significant amount from 107 +/- 2.3 to 121 +/- 1.5 MPa. Elution of tobramycin and amphotericin B was quantified using ultraviolet-visible spectroscopy. Spectroscopy showed that 18% of the antibiotic was released during the first week, with most released in the first 24 hours. The elution of antifungal, however, was unable to be detected after 1 week, with less than 0.03% released. Amphotericin B does not weaken bone cement. Its inability to be delivered at a clinically significant dose gives no clear indication for its incorporation into cement.
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