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Infection reduction using antibiotic-coated inflatable penile prosthesis

Steven K Wilson1, Jurgen Zumbe, Gerard D Henry

  • 1University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

Urology
|September 11, 2007
PubMed
Abstract

Insights

Inflatable penile prosthesis (IPP) infections are reduced with antibiotic-coated implants in first-time surgeries. Revision surgeries require antiseptic washout for similar infection reduction benefits with coated IPPs.

Area of Science:

  • Urology
  • Infectious Disease
  • Surgical Innovation

Background:

  • Inflatable penile prosthesis (IPP) infection is a significant surgical complication.
  • A novel IPP coated with minocycline HCL and rifampin (InhibiZone) was introduced to mitigate infection risk.

Purpose of the Study:

  • To evaluate the infection rate of InhibiZone-coated IPPs.
  • To compare the infection rates with historical data of non-coated IPPs.

Main Methods:

  • A cohort of 467 patients receiving InhibiZone-coated IPPs were followed for infection.
  • Patients were stratified into nondiabetic virgin implants, diabetic virgin implants, revision without washout, and revision with antiseptic washout groups.
  • Infection rates were compared to historical data of non-coated IPPs.

Main Results:

  • No infections occurred in 223 nondiabetic virgin implants.
  • One infection (1%) occurred in 83 diabetic virgin implants.
  • Infection rates for revision patients were 10% without washout and 3% with antiseptic washout.
  • A statistically significant reduction in infection was observed for virgin nondiabetic, virgin diabetic, and revision with washout implants compared to non-coated IPPs.

Conclusions:

  • Antibiotic-coated IPPs demonstrate reduced infection rates in virgin, nondiabetic, and virgin, diabetic patients compared to historical non-coated implants.
  • For revision surgeries, antibiotic-coated IPPs did not reduce infection rates unless an antiseptic solution washout was also employed.

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