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Infection reduction using antibiotic-coated inflatable penile prosthesis.

Steven K Wilson¹, Jurgen Zumbe, Gerard D Henry

¹University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

|September 11, 2007

Summary

Inflatable penile prosthesis (IPP) infections are reduced with antibiotic-coated implants in first-time surgeries. Revision surgeries require antiseptic washout for similar infection reduction benefits with coated IPPs.

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Area of Science:

Urology
Infectious Disease
Surgical Innovation

Background:

Inflatable penile prosthesis (IPP) infection is a significant surgical complication.
A novel IPP coated with minocycline HCL and rifampin (InhibiZone) was introduced to mitigate infection risk.

Purpose of the Study:

To evaluate the infection rate of InhibiZone-coated IPPs.
To compare the infection rates with historical data of non-coated IPPs.

Main Methods:

A cohort of 467 patients receiving InhibiZone-coated IPPs were followed for infection.
Patients were stratified into nondiabetic virgin implants, diabetic virgin implants, revision without washout, and revision with antiseptic washout groups.
Infection rates were compared to historical data of non-coated IPPs.

Main Results:

No infections occurred in 223 nondiabetic virgin implants.
One infection (1%) occurred in 83 diabetic virgin implants.
Infection rates for revision patients were 10% without washout and 3% with antiseptic washout.
A statistically significant reduction in infection was observed for virgin nondiabetic, virgin diabetic, and revision with washout implants compared to non-coated IPPs.

Conclusions:

Antibiotic-coated IPPs demonstrate reduced infection rates in virgin, nondiabetic, and virgin, diabetic patients compared to historical non-coated implants.
For revision surgeries, antibiotic-coated IPPs did not reduce infection rates unless an antiseptic solution washout was also employed.