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Related Concept Videos

Cranial Part of Parasympathetic Division01:18

Cranial Part of Parasympathetic Division

The cranial part of the parasympathetic division plays a crucial role in regulating the visceral functions of the head and specific structures in the neck, thoracic, and abdominopelvic cavities. Preganglionic fibers of the parasympathetic division exit the brain through cranial nerves III (oculomotor), VII (facial), IX (glossopharyngeal), and X (vagus), delivering parasympathetic output to the respective visceral structures.
The vagus nerve (cranial nerve X) alone accounts for approximately 75...

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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Sphenoid sinus paraganglioma: first reported case.

Benjamin D Liess1, Jennifer A Horst, Robert P Zitsch

  • 1Department of Otolaryngology--Head and Neck Surgery, University of Missouri School of Medicine, Columbia, Missouri 65212, USA.

American Journal of Otolaryngology
|September 11, 2007
PubMed
Summary

Paragangliomas are rare head and neck tumors. This case highlights a benign paraganglioma in the sphenoid sinus, discussing its histology and reviewing the literature.

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Area of Science:

  • Otolaryngology
  • Head and Neck Surgery
  • Pathology

Background:

  • Paragangliomas are uncommon neuroendocrine tumors arising from extra-adrenal chromaffin cells.
  • While typically found in the head and neck, their occurrence in the sinonasal tract is exceptionally rare.
  • These benign neoplasms require accurate diagnosis and management.

Observation:

  • A rare case of a benign paraganglioma originating in the sphenoid sinus is presented.
  • The clinical presentation, diagnostic imaging, and surgical management are detailed.
  • Histologic examination revealed characteristic features of paraganglioma.

Findings:

  • The sphenoid sinus paraganglioma demonstrated typical histological findings, including nests of chief cells surrounded by sustentacular cells.
  • Immunohistochemistry confirmed the diagnosis, showing positivity for chromogranin and synaptophysin.
  • Review of the literature indicates a limited number of similar sinonasal paraganglioma cases.

Implications:

  • This case expands the known anatomical distribution of sinonasal paragangliomas.
  • Accurate histological identification is crucial for differentiating from other sinonasal tumors.
  • Understanding the behavior and characteristics of these rare tumors aids in appropriate patient care and surgical planning.