Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunologic approaches to composite tissue allograft.

Aurèle Taieb1, Julio A Clavijo-Alvarez, Giselle G Hamad

  • 1School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

The Journal of Hand Surgery
|September 11, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effects of Growth Hormone on Nerve Regeneration and Alloimmunity in Vascularized Composite Allotransplantation.

Plastic and reconstructive surgery·2023
Same author

Building an Academic Transgender Medicine Center of Excellence: The 5-Year Johns Hopkins Experience.

Academic medicine : journal of the Association of American Medical Colleges·2023
Same author

Cortical reintegration after facial allotransplantation.

Journal of neurophysiology·2022
Same author

The Efficacy of Schwann-Like Differentiated Muscle-Derived Stem Cells in Treating Rodent Upper Extremity Peripheral Nerve Injury.

Plastic and reconstructive surgery·2021
Same author

Reinventing Yourself Virtually: Fifth Annual Society of Asian Academic Surgeons Virtual Conference.

The Journal of surgical research·2021
Same author

Learning to teach: A novel method for assessing surgical trainees' teaching and operative knowledge.

American journal of surgery·2020
Same journal

Current Concepts in Perioperative Guidance and Outcomes in Hand Surgery Patients Taking Glucagon-Like Peptide-1 Receptor Agonists.

The Journal of hand surgery·2026
Same journal

Mesenchymal Stem Cell-Derived Exosomes Combined With 3-Dimensional Hyaluronan-Based Scaffold Promote Tendon-to-Bone Tunnel Healing.

The Journal of hand surgery·2026
Same journal

The Diagnosis and Management of Clenched Fist Syndrome.

The Journal of hand surgery·2026
Same journal

Ultrasound-Assisted Thin Posteromedial Thigh Free Flap for Coverage of Hand and Upper-Extremity Wounds.

The Journal of hand surgery·2026
Same journal

Comparison of One- and Two-knot Techniques in Eight-Strand Flexor Tendon Repair Using Looped Sutures: A Biomechanical Study in a Porcine Model.

The Journal of hand surgery·2026
Same journal

Biomechanical Comparison of Metal Versus Suture and Screw Tension Band Technique for Olecranon Fractures.

The Journal of hand surgery·2026
See all related articles

This review explores immunologic strategies for achieving composite tissue allograft tolerance. It summarizes promising approaches to overcome challenges in reconstructive surgery transplantation.

Area of Science:

  • Immunology
  • Transplantation Science
  • Reconstructive Surgery

Background:

  • Composite tissue allografts present unique immunological challenges.
  • Previous work reviewed pharmacologic strategies for composite tissue allotransplantation.
  • Achieving long-term graft survival remains a significant clinical hurdle.

Purpose of the Study:

  • To discuss the fundamental immunologic principles underlying composite tissue allograft acceptance.
  • To highlight the most promising immunologic approaches for inducing allograft tolerance.
  • To provide a comprehensive overview of options for reconstructive surgery transplantation.

Main Methods:

  • Literature review of immunologic principles in transplantation.
  • Analysis of current and emerging immunologic strategies for tolerance induction.

Related Experiment Videos

  • Synthesis of information on pharmacologic and non-pharmacologic approaches.

    • Main Results:

    • Several immunologic pathways are critical for allograft tolerance.
    • Targeting specific immune cells and cytokines shows promise.
    • Combination therapies may offer synergistic benefits.

    Conclusions:

    • Immunologic tolerance is key to successful composite tissue allografts.
    • Novel immunologic strategies are essential for advancing reconstructive surgery.
    • Further research is needed to translate these approaches into clinical practice.