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Related Experiment Videos

Inflammation, atrophy, and prostate carcinogenesis.

Angelo M De Marzo1, Yasutomo Nakai, William G Nelson

  • 1Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA. ademarz@jhmi.edu

Urologic Oncology
|September 11, 2007
PubMed
Summary
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The exact causes of prostate cancer are unknown. Emerging research suggests that proliferative inflammatory atrophy lesions, possibly caused by inflammation and toxins like charred meat, may precede cancer development.

Area of Science:

  • Oncology
  • Pathology
  • Environmental Health

Background:

  • The etiological agents causing prostate cancer are currently unknown.
  • Emerging evidence suggests pre-cancerous lesions may precede cancer development.
  • These lesions are proposed to represent regenerative epithelium in response to environmental insults.

Purpose of the Study:

  • To explore the potential role of "risk factor" lesions in prostate cancer development.
  • To investigate the link between proliferative inflammatory atrophy, inflammation, and dietary toxins in prostate carcinogenesis.
  • To highlight the need for further research into the drivers of prostate cancer.

Main Methods:

  • Review of emerging evidence on "risk factor" lesions.
  • Analysis of proposed mechanisms involving regenerative epithelium and environmental insults.

Related Experiment Videos

  • Consideration of molecular pathological and animal model studies.

    • Main Results:

    • "Risk factor" lesions, termed proliferative inflammatory atrophy, may precede prostatic intraepithelial neoplasia and early carcinoma.
    • These lesions may arise in the context of inflammation and dietary toxins (e.g., charred meat carcinogens).

    Conclusions:

    • Inflammation and atrophy are potential "driving" factors in prostate carcinogenesis.
    • Further epidemiological, molecular pathological, and animal model research is necessary to confirm this hypothesis.