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Updated: Jul 11, 2026

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
Published on: July 10, 2018
Progress in the discovery and development of glutamate carboxypeptidase II inhibitors
Takashi Tsukamoto1, Krystyna M Wozniak, Barbara S Slusher
1MGI Pharma, Inc., 6611 Tributary Street, Baltimore, MD 21224, USA. takashi.tsukamoto@mgipharma.com
Abstract:
During the past 10 years, substantial progress has been made in the discovery and development of small molecule glutamate carboxypeptidase II (GCP II) inhibitors. These inhibitors have provided the necessary tools to investigate the physiological role of GCP II as well as the potential therapeutic benefits of its inhibition in neurological disorders of glutamatergic dysregulation. This review article details key GCP II inhibitors discovered in the last decade and important findings from preclinical and clinical studies.
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