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Using Mycobacterium smegmatis as a Bioindicator for Zinc-Limited Growth Conditions in Mycobacteria
Published on: September 20, 2024
Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis
Mamta Rawat1, Chantale Johnson, Vanessa Cadiz
1Department of Biology, California State University-Fresno, Fresno, CA 937401, USA.
Biochemical and Biophysical Research Communications
|September 11, 2007
Abstract:
The role of mycothiol in mycobacteria was examined by comparative analysis of mutants disrupted in the four known genes encoding the protein machinery needed for mycothiol biosynthesis. These mutants were sensitive to acid stress, antibiotic stress, alkylating stress, and oxidative stress indicating that mycothiol and mycothiol-dependent enzymes protect the mycobacterial cell against attack from various different types of stresses and toxic agents.

