[Glomerular alterations in glycerol-induced acute renal failure in rabbits]

Experiment was performed to study the glomerular alterations in glycerol-induced acute renal failure in rabbits. At the 3rd, 6th, 24th, 72nd hour after injection of 50% glycerol subcutaneously, glomerular ultrastructural alterations were observed by scanning and transmission electron microscopy. The results showed that impaired glomerular microcirculation and reduced glomerular filtration rate were the main factors accountable for acute renal failure. It seems of great significance to study the effects of toxin-like material in the pathogenesis of acute renal failure.