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Multifocal hyperfunctioning thyroid carcinoma without metastases.

Akiko T Nishida1, Shigeru Hirano, Ryo Asato

  • 1Department of Otolaryngology, Head and Neck Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan. a-nishida@kitano-hp.or.jp

Auris, Nasus, Larynx
|September 11, 2007
PubMed
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This study reports an extremely rare case of multifocal functioning thyroid carcinoma in a 62-year-old woman. Despite hyperfunctioning nodules, no thyrotropin receptor (TSH-R) gene mutations were found.

Area of Science:

  • Endocrinology
  • Oncology
  • Nuclear Medicine

Background:

  • Hyperthyroidism secondary to thyroid carcinoma is uncommon.
  • Cases are typically due to metastatic disease, not primary tumors.
  • Multifocal primary thyroid carcinoma causing hyperthyroidism is exceptionally rare.

Observation:

  • A 62-year-old woman presented with multifocal functioning thyroid carcinoma.
  • Technetium-99m scintigraphy revealed four hyperfunctioning (hot) nodules.
  • Histopathology confirmed papillary carcinoma in all four nodules.

Findings:

  • The study details a rare instance of multifocal papillary thyroid carcinoma presenting as hyperthyroidism.
  • Diagnostic imaging (Technetium-99m scintigraphy) accurately identified the hyperfunctioning nodules.

Related Experiment Videos

  • Genetic analysis excluded mutations in the thyrotropin receptor (TSH-R) gene as the cause.

    • Implications:

    • This case expands the understanding of rare thyroid cancer presentations.
    • It highlights the importance of comprehensive histopathological and molecular evaluation in functioning thyroid nodules.
    • Further research may be needed to elucidate alternative mechanisms driving TSH-R-independent hyperfunctioning thyroid carcinoma.