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Updated: Jul 11, 2026

Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors
Published on: January 19, 2015
Solid-phase synthesis and thermal denaturation study of cyclic PNAs targeting the HIV-1 TAR RNA loop
Gregory Upert1, Mohamed Mehiri, Audrey Di Giorgio
1Laboratoire de Chimie des Molécules Bioactives et des Arômes (LCMBA), UMR UNSA-CNRS 6001, Université de Nice-Sophia Antipolis, 06108 Nice Cedex 2, France.
Abstract:
Cyclic PNAs targeting the HIV-1 TAR RNA loop have been synthesized following a convenient solid-phase strategy which allows on-resin cyclisation. UV-monitored thermal denaturation studies demonstrate that these cyclic PNAs are able to strongly interact with their TAR RNA target, very likely through the formation of a six-base pair stable complex, involving the TAR RNA loop.
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