Sch 213766, a novel chemokine receptor CCR-5 inhibitor from Chaetomium globosum
Shu-Wei Yang1, Ronald Mierzwa, Joseph Terracciano
1Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. shu-wei.yang@spcorp.com
Abstract:
A novel fungal secondary metabolite, Sch 213766 was isolated from the fungal fermentation broth of Chaetomium globosum as the chemokine receptor CCR-5 inhibitor and shown to be the methyl ester of the previously described tetramic acid Sch 210972 on the basis of UV, MS and NMR spectral data analyses. Sch213766 exhibited an IC(50) value of 8.6 muM in the CCR-5 receptor in vitro binding assay.
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