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Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
N-glycosylthioureido aglyco-ristocetins without platelet aggregation activity
Ferenc Sztaricskai1, Gábor Pintér, Erzsébet Röth
1Department of Pharmaceutial Chemistry, University of Debrecen.
The Journal of Antibiotics
|September 11, 2007
Abstract:
The water-soluble N-methoxy-PEG-yl-, N-beta-D-glucopyranosyl- and N-beta-D-maltosylthioureido aglyco-ristocetin were prepared which, in contrast to ristocetin A, did not induce thrombocyte aggregation. The antibacterial activity of N-beta-D-maltosylthioureido aglyco-ristocetin A against MRSA was comparable to that of ristocetin A, while its activity against Enterococcus faecalis (VRE, TSE) is somewhat stronger when compared to those of vancomycin and ristocetin A.

