Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomic footprint of serum urate concentration and urate transporter <i>ABCG2</i> dysfunctional polymorphism: a cross-sectional study.

RMD open·2026
Same author

Ionic liquid cytotoxicity in mouse macrophage J774.1 cells: Effects of alkyl chain length, cation core, and anion type.

The Journal of toxicological sciences·2025
Same author

Changes in urinary albumin levels with dotinurad oral administration in hyperuricemic patients with microalbuminuria: a post hoc analysis.

Clinical and experimental nephrology·2025
Same author

Kidney stones and SGLT2 inhibitors.

Clinical and experimental nephrology·2025
Same author

Genetic background of selected hyperuricemia causing gout with pediatric onset.

Joint bone spine·2025
Same author

First verification of human small intestinal uric acid secretion and effect of ABCG2 polymorphisms.

Journal of translational medicine·2025

Related Experiment Video

Updated: Jul 11, 2026

Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration
10:37

Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

Published on: June 9, 2023

Relationship between hyperuricemia and body fat distribution.

Miho Hikita1, Iwao Ohno, Yutaka Mori

  • 1Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo. miho-h@yc4.so-net.ne.jp

Internal Medicine (Tokyo, Japan)
|September 11, 2007
PubMed
Summary
This summary is machine-generated.

Serum uric acid (SUA) is linked to increased body fat and metabolic syndrome in Japanese men. Higher SUA levels correlate with visceral fat accumulation and metabolic disorders, highlighting its role in metabolic health.

Related Experiment Videos

Last Updated: Jul 11, 2026

Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration
10:37

Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

Published on: June 9, 2023

Area of Science:

  • Metabolic Health
  • Clinical Biochemistry
  • Obesity Research

Background:

  • Serum uric acid (SUA) is a purine metabolite with potential links to metabolic disorders.
  • Obesity, particularly visceral fat accumulation, is a growing public health concern.
  • Understanding the relationship between SUA and metabolic health factors is crucial for preventative strategies.

Purpose of the Study:

  • To investigate the association between serum uric acid (SUA) and body fat distribution.
  • To examine the correlation of SUA with serum lipid profiles and insulin resistance.
  • To determine the relationship between SUA and the prevalence of metabolic syndrome in Japanese men.

Main Methods:

  • A cross-sectional study of 508 Japanese male industrial workers.
  • Measurement of body fat area using computed tomography (CT) at the umbilical level.
  • Definition of metabolic syndrome based on visceral fat accumulation (≥100 cm²) plus two or more criteria: dyslipidemia, hypertension, or hyperglycemia.

Main Results:

  • SUA showed positive correlations with visceral fat area, subcutaneous fat area, total cholesterol, triglycerides, and insulin resistance (Homeostasis Model Assessment index).
  • SUA was negatively correlated with high-density lipoprotein cholesterol levels.
  • Visceral fat area and serum triglyceride levels were identified as significant predictors of SUA in multiple regression analysis.
  • Individuals with metabolic syndrome exhibited significantly higher SUA levels compared to those without (6.67±1.14 mg vs. 6.09±1.14 mg, p<0.0001).
  • Elevated SUA levels were observed with an increasing number of metabolic syndrome components (p<0.0001).

Conclusions:

  • Serum uric acid is significantly associated with visceral fat accumulation in Japanese men.
  • Higher serum uric acid levels are indicative of metabolic syndrome.
  • These findings suggest SUA may serve as a potential biomarker for metabolic dysfunction and visceral obesity.