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Gastric pleomorphic leiomyosarcoma in a Shetland sheepdog
Chun-Ho Park1, Yousuke Ishizuka, Yasuhiko Tsuchida
1Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Amori, Japan.
The Journal of Veterinary Medical Science
|September 11, 2007
Summary
A rare gastric pleomorphic leiomyosarcoma was identified in a Shetland sheepdog. This canine stomach tumor exhibited aggressive cellular features and specific immunohistochemical markers.
Area of Science:
- Veterinary Pathology
- Canine Oncology
- Surgical Pathology
Background:
- Gastrointestinal stromal tumors (GISTs) are uncommon in dogs.
- Leiomyosarcomas arise from smooth muscle cells within the stomach wall.
Observation:
- A 6 cm solitary mass was found in the pyloric antrum of a Shetland sheepdog.
- The mass displayed central necrosis and hemorrhage, with a gray-white appearance.
Findings:
- Microscopic examination revealed a neoplasm of spindle and round cells with high atypia and mitotic activity.
- Immunohistochemistry showed vimentin and desmin positivity, with c-kit negativity.
- Ultrastructural analysis confirmed cytoplasmic myofilaments, consistent with smooth muscle origin.
Implications:
- This case highlights the importance of thorough histopathological and immunohistochemical evaluation for accurate diagnosis of gastric tumors in dogs.
- The findings contribute to the understanding of pleomorphic leiomyosarcomas in veterinary oncology.
- Accurate diagnosis is crucial for determining prognosis and guiding treatment strategies for canine gastric neoplasms.