Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sleep lowers waking theta frequency in the rat hippocampus.

Cell reports·2026
Same author

Subspace communication in the hippocampal-retrosplenial axis.

Nature·2026
Same author

Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice.

Neuron·2026
Same author

The Role of Plasticity in Replay: Stability Through Anti-Hebbian Rules.

Hippocampus·2026
Same author

Sharp wave-ripple clusters enhance hippocampal-neocortical engagement for memory consolidation.

bioRxiv : the preprint server for biology·2026
Same author

Neuronal spiking in the mammalian forebrain is dominated by a heterogeneous ground state.

Neuron·2026

Related Experiment Video

Updated: Jul 11, 2026

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity
07:58

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

Published on: August 28, 2020

Forward and reverse hippocampal place-cell sequences during ripples.

Kamran Diba1, György Buzsáki

  • 1Center for Molecular and Behavioral Neurobiology, Rutgers University, 197 University Ave, Newark, New Jersey 07102, USA. diba@andromeda.rutgers.edu

Nature Neuroscience
|September 11, 2007
PubMed
Summary

Hippocampal place neuron sequences replay in reverse order after a run and in forward order before a run, linked to sharp waves. This suggests a mechanism for forming episodic memories.

More Related Videos

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Related Experiment Videos

Last Updated: Jul 11, 2026

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity
07:58

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

Published on: August 28, 2020

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Memory Research

Background:

  • The hippocampus is crucial for episodic memory formation.
  • Place neurons in the hippocampus encode spatial locations.
  • Neural activity patterns during experience are thought to be replayed during memory consolidation.

Purpose of the Study:

  • To investigate the temporal dynamics of hippocampal place neuron sequences during an experience.
  • To determine if these sequences are replayed and in what order.
  • To explore the relationship between sequence replay and memory processes.

Main Methods:

  • Recorded temporal spike sequences from hippocampal place neurons in rats.
  • Utilized an elevated track task to elicit spatial navigation and experience.
  • Analyzed sequence order during anticipation of and after task completion.
  • Correlated sequence structure with sharp wave activity and place field distances.

Main Results:

  • Hippocampal place neuron sequences recurred in reverse order at the end of the run.
  • Sequences recurred in forward order in anticipation of the run, coinciding with sharp waves.
  • The temporal structure of sequences reflected vector distances between place fields.

Conclusions:

  • Bidirectional re-enactment of temporal sequences by hippocampal place neurons occurs.
  • This replay mechanism may contribute to the establishment of higher-order associations in episodic memory.
  • Findings provide insights into the neural basis of memory consolidation and recall.